Association of synapsin III gene with adult attention deficit hyperactivity disorder.
نویسندگان
چکیده
It was aimed to investigate the association of the synapsin III gene -196 G> A and -631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene -631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene -196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD.
منابع مشابه
The Association of DRD2 Gene TaqI Polymorphism with Attention Deficit Hyperactivity Disorder a Population Sample of Iranian Azeri-children
Background Attention deficit hyperactivity disorder (ADHD) is a multi-factorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotide polymorphisms in DRD2 gene, Taq I A (T/C) and Taq I B (G/A), with ADH...
متن کاملPrevalence of Attention Deficit Hyperactivity Disorder in Adults Hospitalized in Toxicology Ward of Mashhad University of Medical Sciences with Alcohol Poisoning
Background: Attention Deficit Hyperactivity Disorder (ADHD) is a common psychiatric disorder among children and adolescents that can be continued into adulthood in 30 to 50% of cases. Adult ADHD disorder can affect the performance of an individual and may predispose to drug abuse, alcoholism, smoking, sexual offenses, violation of law, educational and other social problems. The coincidences of ...
متن کاملStudy of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri
BackgroundAttention deficit hyperactivity disorder (ADHD), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. The aim of this study was to examine the association of -141 polymorphisms in DRD2 gene with ADHA among Iranian-Azeri population.Materials and Methods A case–control association study included 153 patients with attention defi...
متن کاملVitamin D Status and Its Association with Attention Deficit Hyperactivity Disorder (ADHD) in Children
متن کامل
The impact of synapsin III gene on the neurometabolite level alterations after single-dose methylphenidate in attention-deficit hyperactivity disorder patients
OBJECTIVE To investigate the neurometabolite level changes according to synapsin III gene rs133945G>A and rs133946C>G polymorphisms by using magnetic resonance spectroscopy (MRS) in patients with attention-deficit hyperactivity disorder (ADHD). METHODS Fifty-seven adults diagnosed with ADHD were recruited for the study. The participants were examined by single-voxel (1)H MRS when medication n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- DNA and cell biology
دوره 32 8 شماره
صفحات -
تاریخ انتشار 2013